Nanoparticles made of a polysiloxane matrix and surrounded by
1,4,7,10-tetraazacyclododecane-1-glutaric anhydride-4,7,10-triacetic
acid (DOTAGA)[Gd3+] and
2,2’-(7-(1-carboxy-4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-oxobutyl)-1,4,7-t
riazonane-1,4-diyl)diacetic acid) NODAGA[Ga-68(3+)] have been
synthesized for positron emission tomography/magnetic resonance
(PET/MRI) dual imaging. Characterizations were carried out in order to
determine the nature of the ligands available for radiolabelling and to
quantify them. High radiolabelling purity (>95%) after Ga-68 labelling
was obtained. The MR and PET images demonstrate the possibility of using
the nanoparticles for a combined PET/MR imaging scanner. The images show
fast renal elimination of the nanoparticles after intravenous
injection.Copyright (C) 2014 John Wiley & Sons, Ltd
