Antiepileptic drugs (AED) are increasingly used in the treatment of
migraine. Pregabalin (PGB) is an AED that has been used in the treatment
of partial seizures, of various types of pain, and of certain anxiety
disorders, but to the best of our knowledge, there has been no report on
the use of PGB in the treatment of migraine. We report the case of a
60-year-old female inpatient with depression, long experiencing
migraine, whose migraine symptoms improved markedly after receiving PGB
in combination with escitalopram administered for her depression. The
PGB mechanism of action in conjunction with its structural similarity
with gabapentin, already successfully tested in the treatment of
migraine, provide additional supportive evidence, theoretical and
clinical, respectively, for PGB potential to alleviate migraine
symptoms. However, only carefully randomized, controlled studies, or at
the very least, open-label series of large patient samples treated in a
similar fashion could establish the efficacy of PGB in migraine
treatment
