Post-Sepsis Syndrome (PSS) is comprised of the physical and psychological manifestations affecting sepsis survivors. Sepsis is difficult to diagnose and there are no universal treatment guidelines. A qualitative exploratory single case study was conducted to explore PSS and its effects on quality of life. The case was a community-dwelling 52-year-old adult male, “Tom,� who experienced a near-fatal accident in 2004 and as a result, experienced sepsis three times. Data were collected through a semi-structured interview, lasting one hour. The transcript was read independently by three readers and first and second-level code words and phrases were categorized. Content and thematic analysis were used to identify common themes. The overarching theme, a System out of Whack, was represented by three sub-themes: Hard work, Being lost, and Sort of normal. This study found PSS is a chronic condition requiring long-term management and rehabilitation. In addition, caregivers are critical to the safety and well-being of PSS survivors. Further qualitative research is needed to understand PSS survivors’ and their caregivers’ needs. This research could be used to educate the healthcare team on how to guide long-term care for patients, their families, and caregivers