Duration of additional ovarian function suppression (OFS) in combination with tamoxifen for premenopausal women with or without adjuvant chemotherapy.

Abstract

The x-axis represents each condition of the virtual patient, whereas the y-axis represents the response percentages. (a) Duration of additional OFS in 35-year-old patients with or without adjuvant chemotherapy; 56.8% of clinicians selected to include OFS for 5 years for pT1N0, Ki-67 10%, Oncotype Dx recurrence score (ODX RS) 16, whereas 63.2% selected to include OFS for 5 years for patients without prior chemotherapy under equal pathological conditions. At a higher Ki-67 grade with ODX RS 21, 68.4% and 81.6% of clinicians selected to include OFS for 5 years with and without prior chemotherapy, respectively. (b) Duration of additional OFS in 47-year-old patients with or without adjuvant chemotherapy; 57.9% of clinicians selected to include OFS for only 2 years for pT2N0, Ki-67 10%, ODX 16, whereas 52.6% selected to include OFS for patients without prior chemotherapy under same pathological conditions. Further, 50.0% selected to include OFS for 2 years for pT1N1, Ki-67 10%, and low-risk profile from the MammaPrint assay and finished adjuvant chemotherapy in advance, whereas 50.0% answered to add OFS for 5 years without prior chemotherapy under same pathological condition.</p