Introduction. Prolonged healing of lower extremity ulcers leads to their superinfection,
followed by subsequent amputation of the limb. It is often seen in large chronic wounds with
considerable tissue loss, which become senescent in the inflammatory process. In this case, the
amniotic membrane is used as a biological dressing with a re-epithelialization effect.
Material and methods. For this research activity, the information was obtained by searching
PubMed, using the following keywords: amniotic membrane, diabetic ulcer. The selected articles
are in English and refer exclusively to the use of human amniotic membrane only in trophic
ulcers of the lower limb. It includes an overview of the biologically active factors that induce the
clinical effects that can be seen in amniotic membrane ulcers.
Results. Amniotic membrane allografts have been shown to be beneficial in the treatment of
difficult to heal ulcers when was combined with standard therapy. Only through a meticulous
initial evaluation of the wound is it possible to identify the factors contributing to its complexity.
Conclusions. The amniotic membrane, by its properties, can promote the formation of
granulation
tissue, with the suppression of excessive fibrosis, thus inducing the re-epithelialization of the
chronic ulcer bed
