Abhilash KPP

Barney Isaac TJ

Davis JP

George K

George T

Gunasekaran K

Gupta R

Hazra D

Jasmine S

Jayaseelan L

Joy M

Kanagarajan R

Krishnaraj VRK

Mathews P

Mathiyalagan P

Moorthy M

Peter JV

Pichamuthu K

Rajendiran N

Reddy NP

Rupali P

Selvan S

Varghese GM

\ua9 2022 Elsevier LtdBackground: COVID-19 vaccines were authorised for emergency use to mitigate the impact of the pandemic. This study evaluated the effect of prior vaccination with either Oxford Astra Zeneca\u27s Covishield™ or Bharath Biotech\u27s Covaxin\uae on mortality among symptomatic COVID-19 patients during the second wave of the pandemic in India. Methodology: In this cohort study comprising of RT-PCR confirmed symptomatic COVID-19 patients presenting during April and May 2021, the effect of prior vaccination on mortality (primary outcome), need for hospitalization, oxygen therapy, non-invasive ventilation (NIV) and intensive care unit (ICU) admission were assessed and expressed as risk ratio (RR) with 95% confidence intervals (CI). Results: The mean (SD) age of the cohort (n = 4183) was 46.3 (15.5) years; 17.9% (748/4183) had received at least one dose of Covishield™ and 4.8% (201/4183) had received Covaxin\uae. Mortality was 0.2% (95% CI: 0.2% – 0.7%), 3.5% (1.9–5.2%), 6.2% (0.3–12%) and 12.9% (11.8–14.1%) among fully vaccinated (&gt;2 weeks after two doses), partially vaccinated (&gt;2 weeks after one dose or &lt;2 weeks after two doses), indeterminate (&lt;2 weeks after one dose) and unvaccinated patients respectively. The difference in mortality among unvaccinated vs. fully vaccinated was 12.7% (95% CI: 11.4–13.9%), unvaccinated vs. partially vaccinated was 9.4% (7.4–11.4%) and unvaccinated vs. indeterminate vaccinated was 6.8% (0.8–12.7%). On adjusted analysis, as compared to unvaccinated patients, at least one dose of vaccine reduced the need for hospitalization (RR: 0.40; 95% CI: 0.35–0.47), oxygen (0.33; 0.27–0.40), NIV (0.23; 0.17–0.32), ICU admission (0.18; 0.12–0.27) and mortality (0.18; 0.11–0.29). Conclusion: Among symptomatic COVID-19 patients, prior vaccination with Covishield ™ or Covaxin\uae impacted the severity of illness and reduced mortality during a period of widespread delta variant circulation. Full vaccination conferred greater protection than partial vaccination

Newcastle University E-Prints

Impact of prior vaccination with Covishield<sup>TM</sup> and Covaxin<sup>\uae</sup> on mortality among symptomatic COVID-19 patients during the second wave of the pandemic in South India during April and May 2021: a cohort study

Impact of prior vaccination with Covishield<sup>TM</sup> and Covaxin<sup>\uae</sup> on mortality among symptomatic COVID-19 patients during the second wave of the pandemic in South India during April and May 2021: a cohort study

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