Substance Use Disorder, including Opioid Use Disorder, is a persistent problem within tribal and rural communities across Utah. In response, the Tribal and Rural Opioid Initiative Resource Center delivered an annual summit that brought together community members and local service providers impacted by substance misuse to improve awareness and use of harm reduction resources and reduce social stigma. This article describes the results of the 2022 Intertribal Opioid Wellness Summit