Spencer S. Eccles Health Sciences Library, University of Utah
Abstract
Hereditary Angiopathy with Nephropathy, Aneurysm, and Muscle Cramps (HANAC) Syndrome is a recently described autosomal dominant disorder resulting from COL4A1 mutations. Collagen 4 is common in basement membranes. Abnormal, highly tortuous retinal vessels have been described in affected pedigrees along with intracranial aneurysms, and renal cysts. No optic nerve pathology has previously been described with this entity
