„Contemporary Materials 2021“ : XIV International Scientific Conference : programme and book of abstracts : September 9-10, 2021; Banja Luka, Bosnia and Herzegovin

Filipović Tričković, Jelena G.

Grce, Ana

Kokunešoski, Maja

Valenta Šobot, Ana

Šaponjić, Aleksandra

Valenta-Šobot, Ana

Repository of the Vinča Nuclear Institute (VinaR)

       XIV     ACADEMY OF SCIE  XIV МЕЂУСАВРЕМПРКЊИINTERNATIOCONTEMPPRTHE BOБања Лука Banja L1 NCES AND ARTS OF    НАРОДНИ НЕНИ МАТЕ ОГРАМ РАГА АПСТР  NAL SCIENORARY MA OGRAMMEOK OF AB    , 9 – 10. септембuka, September 9 StatBosfor UTHE REPUBLIC OF SRАУЧНИ СКУРИЈАЛИ 202ДА И АКАТА TIFIC CONFTERIALS 2 AND STRACTSар 2021. годинеth to 10th, 2021 e Commission of nia and Herzegovina NESCO PSKA П 1 ERENCE 021  3         XIV МЕЂУНАРОДНИ НАУЧНИ СКУП САВРЕМЕНИ МАТЕРИЈАЛИ 2021  ПРОГРАМ РАДА  И КЊИГА АПСТРАКАТА   XIV INTERNATIONAL SCIENTIFIC CONFERENCE CONTEMPORARY MATERIALS 2021  PROGRAMME  AND THE BOOK OF ABSTRACTS    4  ОРГАНИЗАТОР НАУЧНОГ СКУПА Академија наука и умјетности Републике Српске   СУОРГАНИЗАТОРИ Alma Mater Europaea Технички универзитет Габрово   ПОКРОВИТЕЉ НАУЧНОГ СКУПА Министарство за научнотехнолошки развој,  високо образовање и информационо друштво   ОДРЖАВАЊЕ СКУПА СУ ПОМОГЛИ UNESCO Универзитетски Клинички центар Републике Српске Комора доктора медицине РС    ОРГАНИЗАЦИОНИ ОДБОР  Академик Драгољуб Мирјанић, предсједник Академик Рајко Кузмановић мр Срђан Рајчевић Академик Бранко Шкундрић Академик Неђо Ђурић Проф. др Есад Јакуповић, дописни члан АНУРС-а Проф. др Илија Железаров Проф. др Лудвик Топлак Проф. др Зоран Рајилић Проф. др Владо Ђајић  Проф. др Саша Вујновић     5  ORGANIZER OF THE CONFERENCE Academy of Sciences and Arts of the Republic of Srpska  COORGANIZERS Alma Mater Europaea Technical University of Gabrovo   UNDER THE PATRONAGE OF Ministry for Scientific and Technological Development,  Higher Education and Information Society   THE SCIENTIFIC CONFERENCE HAS BEEN SUPPORTED BY UNESCO University Clinical Center of Republic of Srpska The Republic of Srpska Medical Association   ORGANIZING COMMITEE  Academician Dragoljub Mirjanić, president Academician Rajko Kuzmanović Srđan Rajčević, MSc Academician Branko Škundrić Academician Neđo Đurić Prof. Esad Jakupović, Ph.D, corresponding member ASARS Prof. Iliya Zhelezarov, Ph.D. Prof. Ludvik Toplak, Ph.D. Prof. Zoran Rajilić, Ph.D. Prof. Vlado Đajić, Ph.D. Prof. Saša Vujnović, Ph.D.       53 PROLONGED EXPOSURE TO MESOPOROUS SILICA DECREASE CELL VIABILITY IN VITRO   Ana Valenta Šobot, Jelena Filipović Tričković, Aleksandra Šaponjić,  Ana Grce, Maja Kokunešoski Department of Physical Chemistry; VINČA Institute of Nuclear Sciences,  National Institute of the Republic of Serbia, University of Belgrade, Belgrade,  Serbia    Abstract: Ordered mesoporous silica SBA-15 structure with high specific surface area enables large pharmaceutical adsorption capacities and promotes its application as a carrier in drug formulations of prolonged-release. The aim of the study was to estimate SBA-15 time and concentration impact on human peripheral blood mononuclear cells viability, as well as cellular morphology and DNA frag-mentation in vitro. SBA-15 mesoporous silica treatment impact on cell viability was monitored at 24, 48 and 72 h time points by TB assay, while at the end of the treatment DNA fragmentation was assessed by colorimetric assay and cellular morphology by dual TMRE/DAPI fluorescent staining. SBA-15 cytotoxic potential rises dependently on time and concentration exposure. After 72 h, all tested con-centrations were cytotoxic and displayed elevated DNA fragmentation correspond-ing to a high level of apoptotic and necrotic cells, as shown by dual fluorescent staining. Short term exposure to SBA-15 material or chemical modification that could influence its physicochemical properties could be a way to lower its toxicity. Key words: SBA-15, cytotoxicity, DNA fragmentation, TMRE staining.    THE IMPORTANCE OF THERMAL COMFORT  OF THE URBAN ENVIRONMENT DURING SPATIAL PLANNING AND CONSTRUCTION   Dijana Đurić1, Neđo Đurić2, Svetlana Stevović3 1Faculty of Civil Engineering Subotica, University of Novi Sad, Serbia 2Academy of Science and Arts, of the Republic of Srpska 3Innovation Center of the Faculty of Mechanical Engineering in Belgrade, Serbia  

Prolonged exposure to mesoporous silica decrease cell viability in vitro

http://vinar.vin.bg.ac.rs/bitstream/id/30684/SM2021-3.pdf

Prolonged exposure to mesoporous silica decrease cell viability in vitro

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