This study was conducted with the aim of calculating the water footprint of the major agricultural products of Isfahan city, Iran and determining the optimal cultivation pattern from the perspective of water footprint and virtual water. To conduct the research, the water requirement of major agricultural products in Isfahan was calculated using CropWat 8 software. Then, the average volume of water consumption, virtual water, water footprint, and water use efficiency of these products for the statistical period 2011-2017 was calculated. The results showed that oilseeds and legumes had the highest water footprint. Forage plants, summer crops, and vegetables had the highest water use efficiency and the lowest water footprint, respectively. Accordingly, the cultivation of oilseeds in Isfahan is not recommended. In the group of wheat grains, in the group of plants, fodder, corn, forage, in the group of vegetables, onions, and in the group of summer vegetables, watermelon with 1815.52, 1720.5, 127949 and 2621,63 m3/ha respectively is recommended for cultivation in Isfahan region due to having less water footprint. Due to recent droughts and water shortages, available water resources should be used in the best way, and crops with lower water requirements and higher yields should be planned
