Objectives: Paraoxonase (PON1) is a high density lipoprotein bound serum esterase that is synthesized by the liver which has ability to metabolize lipid peroxides hence playing an important role in protection against atherosclerosis. Our aim was to evaluate the effect of acute and chronic hyperglycemia on PON1 activity in order to clarify the effect of glucose homeostasis. Besides, the relation of hemoglobin A(1c) with triglyceride, total cholesterol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol and PON1/high density lipoprotein-cholesterol ratios which play role in the development of atherosclerosis was also evaluated
