Ashibe, Kiyo

Fujita, Norihiro

Furuta, Kenjiro

Kuwano, Eiichi

Shirahashi, Hiromitsu

Yamada, Naotaka

Yoshida, Shuhei

A series of alkyl 4-(2-benzylhexyloxy)benzoates and related compounds were synthesized and investigated for their ability to induce precocious metamorphosis in larvae of Bombyx mori, a clear sign of JH deficiency in the hemolymph of early larval stages. In the alkyl 4-(2-benzylhexyloxy)benzoate series, the methyl and ethyl (KF-13) esters induced precocious metamorphosis at relatively low doses. Replacement of the ester group with an amide, alcohol, oxime, ethyl or 3,4-methylenedioxy group eliminated the activity, indicating that the ester group on the benzene ring is essential for activity. A modification was made between the two benzene rings in KF-13. None of the compounds showed higher activity than KF-13 at low doses. The JH activity of synthesized compounds was assayed using allatectomized 4th instar larvae of B. mori. The aniline analog, which showed stronger precocious metamorphosis.inducing activity than KF-13 at higher doses, had obvious JH activity. The n.propyl ester possessing moderate precocious metamorphosis. inducing activity did not show any JH activity. There was some correlation between the ability of compounds to cause precocious metamorphosis and their JH activity

吉田, 周平

古田, 賢次郎

白橋, 浩光

芦邊, 希代

藤田, 雄大

山田, 直隆

桑野, 榮一

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Synthesis and Structure-Activity Relationship of a New Series of Anti-Juvenile Hormone Agents: Alkyl 4-(2-Benzylhexyloxy)benzoates and Ethyl 4-Substituted Benzoates

Synthesis and Structure-Activity Relationship of a New Series of Anti-Juvenile Hormone Agents: Alkyl 4-(2-Benzylhexyloxy)benzoates and Ethyl 4-Substituted Benzoates

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