Click the PDF icon to download the abstrac

Escudero, D

Ives, S

Lagalwar, S

Legesse, S

Reynolds, T

Sheridan, C

Slocum, C

Vidal, K

Zaleski, K

English

TopSCHOLAR

 Mid Atlantic Regional Chapter of the American College of Sports Medicine  Annual Scientific Meeting, November 1st – 2nd, 2019 Conference Proceedings International Journal of Exercise Science, Volume 9, Issue 8 12-648  LC    WHITEThe Effect of Succinic Acid on Metabolic Profile in High-Fat Diet-Induced Obesity and Insulin Resistance Kendall S. Zaleski, Cheyanne Slocum, Daniella Escudero, Caty Sheridan, Saada Legesse, Kavey Vidal,  Sarita Lagalwar, T.H. Reynolds, Stephen J. Ives. Skidmore College, Saratoga Springs, NY  Obesity, insulin resistance, and poor metabolic profile are hallmarks of a high fat diet (HFD), highlighting the need to understand underlying mechanisms. PURPOSE: To determine the effect of succinic acid (SA) on metabolism in high fat diet-induced obesity. METHODS: Animals were randomly assigned to either low fat diet (LFD) or a high fat diet (HFD). Mice consumed their respective diets for 4.5 months and then assigned to the following groups: LFD+vehicle, LFD+SA (0.75 mg/ml), HFD+vehicle, or HFD+SA. Body weight (BW), food and water intake, were tracked weekly. After 6 weeks, insulin, glucose, and pyruvate tolerance tests were completed, and spontaneous physical activity was assessed. Epididymal white adipose tissue (EWAT) mass and in vitro measurements of oxidative skeletal muscle (soleus) respiration were obtained. RESULTS: Expectedly, the HFD increased BW and EWAT mass, and reduced glucose and insulin tolerance. SA significantly reduced EWAT mass, more so in HFD (p<0.05), but had no effect on any in vivo measurements (BW, insulin, glucose, or pyruvate tolerance, nor physical activity, all p>0.05). A significant (p<0.05) interaction was observed between mitochondrial respiration and treatment, where SA increased respiration, likely owed to greater mitochondrial content, as assessed by complex IV activity in both LFD and HFD.  CONCLUSION:  In HFD-induced obesity, coupled with insulin desensitization, no favorable effect of succinic acid on glucose regulation was found, but reduced adiposity was observed. In oxidative skeletal muscle, there was a tendency for increased mitochondrial respiratory capacity, owed to greater mitochondrial content, suggestive of a succinic acid-induced mitochondrial biogenesis.    

The Effect of Succinic Acid on Metabolic Profile in High-Fat Diet-Induced Obesity and Insulin Resistance

https://digitalcommons.wku.edu/cgi/viewcontent.cgi?article=4930&context=ijesab

The Effect of Succinic Acid on Metabolic Profile in High-Fat Diet-Induced Obesity and Insulin Resistance

Abstract

Similar works

Full text

Available Versions

TopSCHOLAR