Please view abstract in the attached PDF file

Bonner, D.

Chantler, P.

DeVallance, E.

Donley, D.

Fournier, S.

Gharib, W.

Pearman, M.

Warden, B. E.

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Relationships between peak oxygen uptake and arterial function: a preliminary study.    Pearman, M., DeVallance, E., Fournier, S., Bonner, D., Warden, B.E., Gharib, W., Donley, D., Chantler, P. West Virginia University, Morgantown, WV  mpearman2@mix.wvu.edu, Edevalla@mix.wvu.edu, sfournier@hsc.wvu.edu, dbonner@hsc.wvu.edu, bwarden@hsc.wvu.edu, wgharib@hsc.wvu.edu ddonley@hsc.wvu.edu, pchantler@hsc.wvu.edu  INTRODUCTION: Aerobic fitness, as measured by VO2peak, is a well-validated predictor of morbidity and mortality in healthy individuals and those with cardiovascular disease.  Resting arterial function, as indicated by carotid to femoral pulse wave velocity (cfPWV: arterial stiffness), and arterial structure as indicated by intima-media thickness (IMT), and carotid diameter (Dc), are correlated to cardiovascular risk. As alterations in arterial health likely impact aerobic capacity, identifying arterial parameters that predict cardiovascular fitness are necessary; however, this relationship has not been fully investigated.  PURPOSE: This preliminarily cross-sectional study examined the relationship between relative peak VO2 and resting arterial function of 51 subjects without overt cardiovascular disease (CVD) (mean age 44.9 ± 11.6).  METHODS: VO2peak was assessed using a staged graded exercise test on a semi-recumbent bicycle until volitional fatigue. cfPWV was measured with Applanation tonometry; IMT and Dc were measured with B mode ultrasound. To account for individual differences in CVD risk each individual was assigned a metabolic risk score based on their age, sex, blood pressure, BMI, triglycerides, HDL, and glucose.  RESULTS: Univariate regression models indicated that VO2peak is significantly related to cfPWV [r = -0.43, p = 0.002], IMT [r = -0.46, p = 0.001], and Dc [r = -0.30, p = 0.035].  For multivariate analysis adjusted for age, sex, and metabolic risk scores, VO2peak remained significantly related to cfPWV [r = -0.29, p = 0.036], IMT [r = -0.32, p = 0.012], and Dc [r = -0.25, p = 0.037].   CONCLUSION: Preliminary data suggest that peak oxygen uptake is independently correlated with arterial health in populations free of overt CVD.  These results suggest that improving peak oxygen uptake may have a favorable effect on arterial function and vice versa.    Research funded in part by the American Heart Association 11CRP7370056 and National Heart, Lung, Blood Institute T32- HL090610  

Relationships between Peak Oxygen Uptake and Arterial Function: a Preliminary Study

http://digitalcommons.wku.edu/cgi/viewcontent.cgi?article=1731&context=ijesab

Relationships between Peak Oxygen Uptake and Arterial Function: a Preliminary Study

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