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Alexander-Holowatz, L.

Craighead, D.

Dahmus, J.

Kenney, W. Larry

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Low-density lipoprotiens, body mass index, and the female sex are predictors of reduced cutaenous reactive hyperemia in human skin    Craighead, D. Dahmus, J. Kenney, WL, FACSM. Alexander-Holowatz, L, FACSM. Penn State University, University Park, PA   dhc139@psu.edu, jdd5081@psu.edu, lma191@psu.edu, w7k@psu.edu   Purpose: The human cutaneous circulation is a representative vascular bed to assess systemic microvascular dysfunction associated with preclinical cardiovascular diseases. Laser speckle contrast imaging (LCSI) is a state-of-the-art method used to measure skin blood flow (SkBF), imaging a larger surface area compared to single-point laser-Doppler flowmetry.  Using LCSI, we sought to determine what cardiovascular risk factors were most predictive of the cutaneous reactive hyperemic (RH) response in human subject with a broad range of age cardiovascular disease risk factors. Methods:  A standardized RH protocol consisting of three, five minute suprasystolic occlusions was performed on 38 human subjects ranging in age (19-82 years), body mass index (BMI:  19.7-36.2 kg/m2), mean arterial pressure (MAP: 67-99 mmHg) and serum low-density lipoproteins (LDL) (54-185 mg/dl). Following the occlusion, the RH SkBF response was imaged using the full-field LCSI. Regions of interests (ROI) were determined, integrated, and normalized to cutaneous vascular conductance (CVC, integrated ROI flux/MAP). A stepwise regression analysis was performed to determine the best predictors of RH parameters including the peak SkBF, and the total hyperemic response (THR). Results: Subject sex (R2=0.158, P<0.001), BMI (R2=0.195, P<0.001), and serum LDL (R2=0.27, P<0.001) were all significant predictors of peak RH CVC.  Both age (R2=0.108, P<0.001) and BMI (R2=0.147, P=0.012) significantly predicted the THR. Conclusion: Increased BMI, serum LDL, and the female sex, are associated with decreased peak SkBF response during RH. Increased age and BMI are associated with a decreased total hyperemic response. (NIH R01 AG07004-19-25)  

Low-density Lipoprotiens, Body Mass Index, and the Female Sex Are Predictors of Reduced Cutaenous Reactive Hyperemia In Human Skin

http://digitalcommons.wku.edu/cgi/viewcontent.cgi?article=1680&context=ijesab

Low-density Lipoprotiens, Body Mass Index, and the Female Sex Are Predictors of Reduced Cutaenous Reactive Hyperemia In Human Skin

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