International Journal of Exercise Science 9(2): 205-213, 2016. The purpose of this study was to investigate the effects of ingesting a pre-workout commercial energy drink supplement on multiple parameters of physical performance, including upper body and trunk muscular endurance, muscular power, and repeated sprint speed. 19 college-aged males (n = 8) and females (n = 11) participated in this randomized, double-blind, parallel groups study. At baseline and post-testing (about one week after baseline testing), anaerobic power (assessed via a countermovement vertical jump), muscular endurance (assessed via YMCA bench press test and a curl-up test), and repeated sprint speed were assessed. Thirty minutes prior to post-testing, subjects ingested one serving (1.75 ounces [37 ml]) of a calorie-free, caffeine-containing pre-exercise energy supplement (Redline Power Rush by VPX) (n = 10) or an isovolumetric and similar tasting placebo beverage (n = 9). While vertical jump, YMCA bench press, and repeated sprint speed improved from pre to post testing in both treatment groups, there were no differences between the energy drink and placebo beverages. Curl-up endurance performance improved following the energy drink ingestion but did not improve following placebo ingestion. However, this observation also failed to reach statistical significance (p = 0.120). A possible explanation for the lack of effect of the pre-exercise energy drink to enhance physical performance was the relatively low amount of caffeine that was present in the beverage (providing an average of 2.4 mg caffeine/kg body mass)