High-grade gliomas (HGG) are the most frequent primary central nervous system tumors; treatment of HCGs
includes surgery and post-operative conformal radiotherapy associated with temozolomide (TMZ or
procarbazine/lomustine/vincristine [PCV], specifically in patients with anaplastic oligodendrogliomas or
anaplastic oligoastrocytomas). However, recurrence is common. Re-irradiation has been utilized in this
setting for years and remains a feasible option, although there is always a concern regarding toxicity.
Modern high-precision conformal techniques, including stereotactic radiosurgery (SRS), could improve the
therapeutic ratio by delivering high biologically equivalent doses while reducing high-dose radiotherapy (RT)
to normal brain tissue. In this paper, we present the results obtained after prolonged follow-up in patients
who underwent SRS as a treatment for recurrent high-grade gliomas at San Francisco Hospital in Madrid,
Spain
