ABSTRACT
The success of organ transplants and their consideration
as a clearly established treatment in some
indications is due to the development of immunosuppressant
drugs. While it was not the first of the drugs
to be employed, the introduction of cyclosporin in the
1980s in immunosuppressant treatment made possible
an increase in the number of transplants and the
success of this practice. From then onwards, immunosuppression
has been based on the use of a combination
of drugs, initially cyclosporin, corticoids and azathioprine.
In recent years new drugs have been
introduced that have opened up the possibilities of
treatment. But many pending questions remain, due
to the toxicity associated with their use and the possibility
of interaction with other drugs, which complicates
their use and can compromise the prognoses of
these patients.
Calcineurin inhibitors and mTOR are the drugs
involved with greater frequency in interactions with
other drugs, which makes it necessary to anticipate
this possibilit
