This report presents a female diagnosed with a frontoparietal interhemispheric
meningosarcoma who, parallel to the clinical worsening, revealed an increase in
the genetic instability (in bleomycin cultures) and the complexity of the
karyotypes, with the acquisition of a clonal deletion of 17p13 (the locus for the
TP53 tumor suppressor gene). The genetic findings of this patient suggest that
the increased genetic instability could contribute to tumor progression as well
as to treatment resistance, possibly in the background of the clonal deletion of
TP53
