Argonaute-based nucleic acid detection system

Abstract

The invention relates to a detection system for a target nucleic acid molecule that is based on a short Argonaute protein in combination with a TIR-APAZ or SIR2-APAZ protein, and the conversion of a nicotinamide adenine dinucleotide (NAD). The invention further relates to methods of detecting a specific nucleic acid molecule in a sample comprising said detection system