A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies

Abstract

Passive immunization against toxic misfolded proteins could offer protection against neurodegenerative disease. Lathuilière et al . report the development of a retrievable device to encapsulate cells secreting recombinant anti-amyloid-β antibodies. When implanted in mouse models of Alzheimer's disease, the system delivers antibodies to the brain and reduces amyloid and tau pathologies