Shi, Shaojun

English

Life revolves around death. The process of programmed cell death also calledcellular suicide, is a highly regulated mechanism that is important during (embryonic)development and tissue homeostasis. The most well-studied type of programmedcell death is necroptosis, which features characteristics of both apoptosis andnecrosis. However, due to suboptimal experimental animal and cell line models,detailed knowledge of these processes is still largely unknown.The work in this thesis describes how different types of programmed cell death playa role in cholangiopathies, liver cancer, and liver transplantation. For this, a 3-dimensional organoid culture method to grow and expand cholangiocyte progenitorsfrom healthy donors, patients suffering from cholangiopathies, andcholangiocarcinoma, has been used (Part I). Furthermore, the mechanism ofprogrammed cell death in liver ischemia-reperfusion injury during livertransplantation is described, based on patients’ biopsies and human cholangiocyteorganoids culture (Part II)<br/

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Programmed cell death in cholangiopathies, liver cancer, and liver transplantation

https://pure.eur.nl/files/61857184/thesisshaojunshiwithout_chapter_3_and_6_62daa6e72c5ba.pdf

Programmed cell death in cholangiopathies, liver cancer, and liver transplantation

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