In an increasingly digital world, there are fast-paced developments in fields such as Artificial Intelligence, Machine Learning, Data Mining, Digital Twins, Cyber-Physical Systems and the Internet of Things. This paper reviews and discusses how these new emerging areas relate to the traditional domain of building performance simulation. It explores the boundaries between building simulation and these other fields in order to identify conceptual differences and similarities, strengths and limitations of each of these areas. The paper critiques common notions about these new domains and how they relate to building simulation, reviewing how the field of building performance may evolve and benefit from the new developments