Background: There are fetuses demonstrating very large myelomeningocele lesion which can not be covered with autochothonous skin. Material and Methods: We use Integra™ artifical skin for intrauterine coverage of the back lesion. A reverse latissimus dorsi flap was used postnataly to reinforce the repair site. Conclusion: Integra™ appears to be a suitable coverage for large soft tissue defects in utero. Moreover, a postnatal reverse latissimus dorsi flap appears to markedly strengthen tissue coverage over a spinal cord rescued in uter
