A re-assessment of the historic seismicity of the central sector of the Colombian Eastern Cordillera (EC) is made by revision of bibliographic sources, by calibration with modern instrumental earthquakes, and by interpretations in terms of current knowledge of the tectonics and seismicity of the region. Throughout the process we have derived an equation to estimate Mw for shallow crustal earthquakes in Colombia using the length of isoseismal VIII, LVIII: [Mw]=1.85logLVIII+2.7 We also derived an equation to evaluate Mw for Colombian crustal earthquakes using the rupture length, L, estimated generally from the aftershock distribution of strong earthquakes: [Mw]=1.77logL+3.9 We calculated average attenuation parameters for intermediate depth and shallow earthquakes that may be used, combined with other observations, to estimate the focal depth of historical events. Our final picture shows three distinct regions of the Colombian Eastern Cordillera (EC) where historical earthquakes are distributed. (a) The southern sector, from the Páramo de Sumapaz down to the Colombian Massif where the largest crustal earthquakes have occurred (1827, M ∼ 7 3/4; 1967, Mw = 7.0). (b) The central sector, between the Páramo de Sumapaz and Tunja with moderate to large earthquakes associated to the reverse faults on the piedmonts (the 1805 earthquake, M ∼ 6 3/4, on the western flank, and the 1743, 1923 and 1995 with M ∼ 6 1/2, 6 3/4, and 6.5, respectively, on the eastern flank). (c) The northern sector, to the north of Tunja, which is characterized by recurrent earthquakes probably associated with major reverse faults in the axial zone (e.g., 1646, I0 = VIII; 1724, M ∼ 6 3/4; 1755, I0 ≥ VIII; and 1928, M ∼ 5 3/4). Two events appear to be related to the axial faults to the south of Bogotá: those in 1644 (M ∼ 6) and 1917 (M = 7.1). The 1785 earthquake might have been an intraplate event in the subducting plate under the EC. Events in 1616 and 1826, which caused damage along the axial zone of the Cordillera near Bogotá, have no historical records precise enough to allow the estimation of their location and size, but their epicentres are probably not farther than some tens of kilometers from Bogot