Hewer, E.

Schwartz, K. M.

Slopis, J. M.

Stippich, C.

Yu, Y.

Zipp, L.

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1 3CorrespondenCeIntroductionGiant cell glioblastoma (GCG) is considered to be a subtype of glioblastoma multiforme (GBM). This malignant tumor of glial origin is a grade IV tumor according to the current classification of the World Health organization (WHo, [1]) and accounts for approximately 5% of GBMs and 0.8% of all brain tumors [2]. In pediatric patients supratentorial tumors are less common than infratentorial tumors with a ratio of approximately 1:2. The GBMs account for 7–9% of all intracranial tumors and 0.6–7.9% of all GBMs occur during childhood [3]. These statistics demonstrate that GCG is an exceedingly rare tumor mainly described in isolated case reports or series with a predilection for younger pati-ents [2, 4]. The GCGs arise from white matter, as do the common GBMs and have a tendency to involve the fron-tal and temporal lobes [2, 5]. The higher predilection for the cerebral hemispheres than a typical GBM, probably in addition to histological variations, may be responsible for the better prognosis as the location means that gross total resection is more frequent. The tumor is macroscopically well-circumscribed and histologically shows numerous bizarre multinucleated giant cells with an abundant reticu-lin network and a high frequency of p53 mutations [6, 7]. In general terms GBM has a poor prognosis with a mean survival time ranging from 12–15 months in adults [8]. In pediatric patients with high grade astrocytoma the outcome is slightly better but still remains poor with survival times ranging from 15–42 months [9, 10]. In standard GBM tre-atment protocols tumor resection is followed by irradiation and dnA alkylating chemotherapy. Adding temozolomide as a chemotherapy drug significantly improved outcome in newly diagnosed GBM [11, 12] and the median survi-val time improved from 12.1 to 14.6 months and the 2-year survival rate reached 25.6% compared to 10.4% previously when adding temozolomide to standard GBM treatment protocols [13, 14]. other factors associated with decreased survival in GBM include but are not limited to larger tumor size [15], higher age [16] as well as bilateral location [17]. The GCG is associated with longer survival times compared to GBM, ranging from 15 months up to 17 years in adults [5, 18] and ranging from 14 months up to 12 years in children [4, 19].one case report also reported a long-term survival with a late transformation to gliosarcoma [6].Case ReportThis article reports the case of an 8-year-old boy presenting at the university hospital with vomiting and a seizure last-ing approximately 2 min. A second generalized seizure was Clin neuroradiol (2012) 22:359–363doI 10.1007/s00062-012-0130-9Magnetic Resonance Imaging and Computed  Tomography Findings in Pediatric Giant Cell GlioblastomaL. Zipp · K. M. Schwartz · E. Hewer · Y. Yu · C. Stippich · J. M. SlopisL. Zipp, Ms () · J. M. slopis, Mddepartment of pediatrics, Md Anderson Cancer Center,  1515 Holcombe Blvd., 77030 Houston, Texas, UsAL. Zipp, Ms · C. stippich, Mddepartment of neuroradiology, University Hospital Basel,  petersgraben 4, 4031 Basel, switzerlande-mail: lisa.zipp@web.deK. M.  schwartz, Mddepartment of radiology, Mayo Clinic, 200 First st sW,  55905 rochester, Minnesota, UsAe. Hewer, Mddepartment of neuropathology, University Hospital Basel, petersgraben 4, 4031 Basel, switzerlandY. Yu, phddepartment of radiation oncology, Kimmel Cancer Center,  Thomas Jefferson University, 111 s. 11th street,  19107 philadelphia, pennsylvania, UsAreceived: 10 november 2011 / Accepted: 3 January 2012 / published online: 28 January 2012© springer-Verlag 20121 3360 L. Zipp et al.observed later the same day. Magnetic resonance imaging (MrI) was performed on a 1.5 T Magnetom symphony scanner (siemens Medical systems, erlangen, Germany) with the following imaging parameters: T2-weighted sequence Tr/Te = 4920/104 ms, T1-contrast-enhanced sequence Tr/Te = 663/17 ms, T1-fat-saturated contrast- enhanced sequence Tr/Te = 559/17 ms, diffusion-weighted imaging and apparent diffusion coefficient (dWI/AdC) sequence Tr/Te = 4400/105 ms, slice thickness 5 mm. As MrI contrast agent 10 ml of dotarem (gadolinium-tetraa-zacyclododecanetetraacetic acid, Gd-doTA) was adminis-tered. Computed tomography (CT) was performed using a 10-row multidetector CT scanner (sensation 10, siemens Medical systems, erlangen, Germany) with a slice thick-ness of 3 mm. As CT contrast agent 45 ml of ultravist was administered. The MrI and CT findings are demonstra-ted in Fig. 1. The CT image after contrast administration displayed an enhancing mass adjacent to the frontal horn of the left lateral ventricle and MrI showed a predominantly T2-hyperintense mass with central nodular enhancement and surrounding T2 hyperintensity.Fig. 1 An 8-year-old boy with pathologically documented giant cell glioblastoma. Contrast-enhanced axial (a) and coronal (b) T1-weight-ed magnetic resonance imaging (MrI) and axial postcontrast com-puted tomography (CT, c) images demonstrate an enhancing mass centered at the anterior limb of the left internal capsule. (d) Axial T2-weighted MrI image reveals moderate surrounding T2 hyperintensity consistent with tumor and edema involving the basal ganglia and the internal and external capsules and compressing the anterior horn of the left ventricle. (e) diffusion-weighted image (dWI) signal intensity increases in the tumor corresponding to T2 signal changes (edema and T2 shine through). The semilunar T1 contrast-enhancing part has very low dWI signals corresponding to facilitated diffusion and indicating reduced cellularity. (f) Corresponding apparent diffusion coefficient (AdC) map. The AdC value setting a region of interest of 150 mm2 within the tumor was 1168.5 ± 1.7 as mean value with a range between 976 (minimum value) and 1313 (maximal value)            1 3361Magnetic resonance Imaging and Computed Tomography Findings in pediatric Giant Cell GlioblastomaA stereotactic biopsy revealed a GCG with typical p53 accumulation in immunohistochemical staining indicating presence of Tp53 mutation in the tumor as demonstrated in Fig. 2. Focal necrosis and beginning endothelial prolifera-tion were identified, typical features to differentiate a GBM from an anaplastic WHo III glioma. expression of glial fibrillary acidic protein (GFAp) and microtubule-associated protein 2 (MAp-2) was evident and the Ki-67 marker deter-mined a proliferation rate of 20% (not shown). The diagno-sis of GCG was confirmed by the Brain Tumor reference Center of the German society of neuropathology and neu-roanatomy at the University Hospital of Bonn, Germany.DiscussionGiant cell glioblastoma is a rare subtype of GBM and the diagnosis of GCG has significant clinical consequences. Children with a malignant glioma have a slightly better prognosis than their adult counterparts [9, 10]. In a collec-tion consisting of 39 pediatric patients with supratentorial and cerebellar malignant gliomas, including 1 GCG, the extent of resection was the strongest predictor of outcome [20]. In the case of a GCG where the prognosis seems to be better according to the current literature, maximum surgi-cal resection with the combination of aggressive adjuvant radiochemotherapy (using for instance the protocols of the HIT-GBM trials [19]) may lead to better outcome. Howe-ver, a previous publication could not confirm a better overall survival and event-free survival in pediatric GCGs compa-red to GBM [19]. The GCGs are of glial origin [21] and the-refore stain positively for GFAp. nuclear p53 accumulation was detected in the biopsy, indicating a Tp53 mutation con-sistent with previous work on the genetic profile of GCGs with a p53 mutation frequency of more than 70% whereas epidermal growth factor receptor (eGFr) amplification was found very rarely [22, 23]. The detected proliferation rate for the antibody against ki67 was also consistent with previ-ous case reports determining similar or the same prolifera-tion index of 20% as in this case [4].The differential diagnosis based on imaging and clinical presentation is broad, including low-grade tumors, such as ganglioglioma, pleomorphic xanthoastrocytoma, and oli-godendroglioma. High-grade neoplasms and infections can Fig. 2 (a) Histologically the brain biopsy showed a cellular, mitotically active glial tumor (a: original magnification x40) and (b, c) bizarre, occasionally multinucleated giant tumor cells were also seen. (d) Immuno-histochemically a pronounced nuclear p53 accumulation was present in most tumor cells. (b–d: original magnification x200) staining: a–c: hematoxy-lin and eosin; d: immunohisto-chemical staining for p53            1 3362 L. Zipp et al.also have a similar appearance. due to the fact that seizures and headache are very common and non-specific symptoms occur in different brain tumors, it is crucial to perform radio-logical scrutiny to narrow the diagnosis to improve patient management prior to treatment or biopsy.In this case the radiological findings of an exceedingly rare primary brain tumor, a GCG, a GBM subtype probably with a better prognosis are presented. Central homogeneous enhancement is present, different than the heterogeneous peripheral enhancement often seen in classical GBMs. The contrast-enhancing part revealed a low signal on dWI indi-cating reduced cellularity.Larger studies evaluating imaging findings in GCGs are needed to determine if these imaging characteristics are typi- cal of GCGs and can help distinguish GBMs from GCGs. Alt-hough rare preoperative consideration of this entity should be included when radiologically and clinically appropriate which in turn might impact different patient care in pediatric GCGs and GBMs. In a retrospective analysis significantly more pediatric patients with GCG were treated according to the HIT-GBM-d protocol, a very intensive chemotherapy regimen, compared to pediatric GBM patients [19]. This study described the use of different neurooncological tre-atment protocols for GBM and GCG. The outcome of the GCG patients treated with the more intensive chemotherapy regimen was not analyzed. Hence further investigations are necessary in terms of an outcome benefit in GCG before a more intensive chemotherapy regimen can be justified. nevertheless it is crucial to consider that histological confir-mation of the exact diagnosis is required before appropriate treatment decisions can be made.Conclusionspreoperative consideration of a GCG should be included in pediatric patients when radiologically and clinically appro-priate as well as histologically proven which in turn might influence future therapy approaches towards a more inten-sive chemotherapy regimen. To the best of our knowledge this is the first manuscript demonstrating MrI and CT fin-dings in a patient with GCG.Acknowledgment We wish to thank prof. T. pietsch of the Brain Tumor reference Center of the German society of neuropathology and neuroanatomy at the University Hospital of Bonn, Germany for confirmation of the histological diagnosis.Conflict of Interest The authors declare that they have no conflict of interest.References 1. Kleihues p, Louis dn, scheithauer BW, rorke LB, reifenberger G, Burger pC, et al. The WHo classification of tumors of the nervous system. J neuropathol exp neurol. 2002;61(3):215–25; discussion 226–9. 2. de prada I, Cordobes F, Azorin d, Contra T, Colmenero I, Glez-Mediero I. pediatric giant cell glioblastoma: a case report and review of the literature. Childs nerv syst. 2006;22(3):285–9. 3. Artico M, Cervoni L, Celli p, salvati M, palma L. supratentorial glioblastoma in children: a series of 27 surgically treated cases. Childs nerv syst. 1993;9(1):7–9. 4. Klein r, Molenkamp G, sorensen n, roggendorf W. Favorable outcome of giant cell glioblastoma in a child. report of an 11-year survival period. 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Magnetic Resonance Imaging and Computed Tomography Findings in Pediatric Giant Cell Glioblastoma

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Magnetic Resonance Imaging and Computed Tomography Findings in Pediatric Giant Cell Glioblastoma

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