High prevalence of myeloid neoplasms in adults with non–Langerhans cell histiocytosis

Abstract

International audienceKey Points Some 10.1% of adults with non–Langerhans cell histiocytosis have a concomitant myeloid neoplasm with each often harboring distinct mutations. The presence of distinct kinase mutations in histiocytosis and myeloid neoplasms resulted in discordant responses to targeted therapy