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Thymosin beta 4 gene silencing decreases stemness and invasiveness in glioblastoma

Abstract

Glioblastomas are incurable malignant primary brain tumours. Wirsching etal. investigate the effects of altered expression of thymosin beta 4 (TB4), a polypeptide implicated in neural development and wound healing, in glioma models. TB4 silencing inhibited migration and invasion of glioma cells invitro, and enhanced survival of glioma-bearing mic

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