We present analytical derivations and 2-D numerical simulations that quantify magnitudes of deviatoric stress and tectonic overpressure (i.e. difference between the pressure, or mean stress, and the lithostatic pressure) by relating them to lateral variations in the gravitational potential energy (GPE). These predictions of tectonic overpressure and deviatoric stress associated with GPE differences are independent of rock rheology (e.g. viscous or elastic) and rock strength. We consider a simple situation with lowlands and mountains (plateau). We use a numerical two-layer model consisting of a crust with higher Newtonian viscosity than that in the mantle, and also a three-layer model in which the two-layer lithosphere overlies a much less viscous asthenosphere. Our results (1) explain why estimates for the magnitude of stresses in Tibet, previously published by different authors, vary by a factor of two, (2) are applied to test the validity of the thin sheet approximation, (3) show that the magnitude of the depth-integrated tectonic overpressure is equal to the magnitude of the depth-integrated deviatoric stress if depth-integrated shear stresses on vertical and horizontal planes within the lithosphere are negligible (the thin sheet approximation) and (4) show that under thin sheet approximation tectonic overpressure is required to build and support continental plateaus, such as in Tibet or in the Andes, even if the topography and the crustal root are in isostatic equilibrium. Under thin sheet approximation, the magnitude of the depth-integrated tectonic overpressure is equal to the depth-integrated horizontal deviatoric stress, and both are approximately 3.5 × 1012 N m−1 for Tibet. The horizontal driving force per unit length related to lateral GPE variations around Tibet is composed of the sum of both tectonic overpressure and deviatoric stress, and is approximately 7 × 1012 N m−1. This magnitude exceeds previously published estimates for the force per unit length required to fold the Indo-Australian Plate south of India, and hence the uplift of the Tibetan plateau could have folded the Indian Plate. We also discuss the mechanical conditions that are necessary to achieve isostasy, for which the lithostatic pressure is constant at a certain depth. The results show that tectonic overpressure can exist at a certain depth even if all deviatoric stresses are zero at this depth, because this tectonic overpressure is related to horizontal gradients of vertical shear stresses integrated across the entire depth of the lithosphere. The magnitude of the depth-integrated tectonic overpressure of 3.5 × 1012 N m−1 implies that the pressure estimated from observed mineral assemblages in crustal rocks is likely significantly different from the lithostatic pressure, and pressure recorded by crustal rocks is not directly related to depth. In case of significant weakening of the entire lithosphere by any mechanism our analytical and numerical studies provide a simple estimation of tectonic overpressure via variations in GP