The inotropic effects of hypercapnia have been examined in the isometric papillary muscle preparation from the cat. The initial stage of depression which resulted from the acute induction of hypercapnia was followed by a significant degree of spontaneous recovery during the next hour. When the carbon dioxide concentration was returned to normal a temporary rebound in performance to well above control levels was observed. These findings are interpreted as being due to slow changes arising within heart muscle itself which partially compensate for the direct inotropic depressant effect of hypercapni