The great behavioral heterogeneity observed between individuals with the same
psychiatric disorder and even within one individual over time complicates both
clinical practice and biomedical research. However, modern technologies are an
exciting opportunity to improve behavioral characterization. Existing
psychiatry methods that are qualitative or unscalable, such as patient surveys
or clinical interviews, can now be collected at a greater capacity and analyzed
to produce new quantitative measures. Furthermore, recent capabilities for
continuous collection of passive sensor streams, such as phone GPS or
smartwatch accelerometer, open avenues of novel questioning that were
previously entirely unrealistic. Their temporally dense nature enables a
cohesive study of real-time neural and behavioral signals.
To develop comprehensive neurobiological models of psychiatric disease, it
will be critical to first develop strong methods for behavioral quantification.
There is huge potential in what can theoretically be captured by current
technologies, but this in itself presents a large computational challenge --
one that will necessitate new data processing tools, new machine learning
techniques, and ultimately a shift in how interdisciplinary work is conducted.
In my thesis, I detail research projects that take different perspectives on
digital psychiatry, subsequently tying ideas together with a concluding
discussion on the future of the field. I also provide software infrastructure
where relevant, with extensive documentation.
Major contributions include scientific arguments and proof of concept results
for daily free-form audio journals as an underappreciated psychiatry research
datatype, as well as novel stability theorems and pilot empirical success for a
proposed multi-area recurrent neural network architecture.Comment: PhD thesis cop