Maire, R.

Suter, PM

Vetter, W.

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148A ASH ABSTRACTS126PREVALENCE OF ARTERIAL HYPERTENSIONIN CHILDREN AND ADOLESCENTS.INFLUENCE OF OBESITY.M.E. Macedo'##, D. Trigueiros" and F. Freitas'"Service de Terapeutica Medica, Faculdade deMedicina, ##Centro de Citologia Experimental,Universidade do Porto, "ISCTE, Universidade deLisboa, Portugal.Obesity is associated with elevated blood pressure (BP)mainly in adults. It has been suggested that body fatpatterning plays a role in the etiology of hypertension. Thisrelationship also exists in children, however it is less known.The aim of this study was to evaluate the prevalence ofhypertension in children and adolescents. The influence ofobesity on this hypertensive population was investigated aswell as the familial aggregation. 889 children 5-18 years oldof both sexes (389 boys and 500 girls) from the North ofPortugal and their parents have been studied. Systolic bloodpressure( SBP). diastolic blood pressure (DBP), weight,height, triceps skinfold, body mass index (BMI) and sexualmaturation were measured. The criterion of hypertension wasdefined as the BP being higher than the 95 percentile. Allvariables were converted to age and sex in specific Z-scores.A SPSS package was used.We have found 47 (5.2%) hypertensive people of bothsexes. The children of this group were compared with thenormotensive group. The hypertensive children are heavier(P< 0.(05) and more obese (P< 0.(001) than the others. Nodifference was found for sexual maturation and height. Theparents of hypertensive group had higher SBP (p<O,OOI),and OBP (p<O.O I), were heavier (p<O.OOI) and more obese(p«J.O IJ than the parents of normotensive group.In conclusion: obesity is an important factor in childrenhypertension. Hypertensive children are more likely to comefrom families with histories of hypertension or obesity.KeyWordschildren, hypertension, obesity, familialaggl·eganon.128DOES DYSLIPIDEMIA AND INSULIN (INS) RESISTANCERELATE TO BLOOD PRESSURE (BP), AGING AND BMI?K. Masuo*, H. Mikami*, T. Ogihara*, and M.L. Tuck!",Department of Geriatric Medicine, Osaka UniversityMedical School, Osaka, Japan, and 1UCLA School ofMedicine, Los Angeles, CA.To evaluate the relationships between dyslipidemia,INS resistance, BP, aging, and BMI, we measured BPfasting blood glucose (BG), plasma INS, total cholesterol(T-ch), HDL, VLDL, LDL-ch, and triglyceride (TG) afterovernight fasting and area under the curve (AUe) ofBG and INS after 75g glucose ingestion in 1023Japanese, non-obese, non-diabetic males (agerange:18-103 yrs; BMI range: mean BP correlatedsignificantly with fasting INS (R=O.16, P=O,OO07), AUeofINS (R=O.17, P=O,004), T-ch (R=O.15, P=O.OO18), VLDL-ch (R=O.19,P=O.OOOl), LDL(R=O.15,P=O.OOlS), TG (R=O.13,P=O.OO56), and BMI (R=0.36, P=O.OOOl), and BMIcorrelated significantly with fasting INS (R=O.28,P=O.OOOl), T-ch(R=O.26, P=O.OOOl), VLDL (R=O.38,P=O.OOOl), and TG (R=0.31, P=O.OOOl). Furthermore, agecorrelated significantly with T-ch (R=O.19, P=O.OOOl)and TG (R=0.36, P=O.OOOl). These results suggest that inJapanese non-obese, non-diabetic males, abnormalityin lipid metabolism, reduced INS sensitivity and obesityplay important roles in the onset and maintenance ofhypertension.AfH-APRIL 1995-VOL.8, NO.4, PART 2127IS THE EFFECT OF ETHANOL ON BLOODPRESSURE INDUCED BY AN INCREASEDWAIST/HIP RATIO?PM Suter, R Maire, and W Vetter'. MedicalPoliclinic, University Hospital of ZOrich, ZOrich,SwitzerlandAbdominal accumulation of fat is associated withan unfavorable cardiovasular risk factor profileincluding hypertension. Moderate ethanolconsumption (EC) is associated with elevatedsystolic and diastolic blood pressure (sys/dia BP).EC frequency and other life style factors (i.e. diet,exercise, stress perception, smoking) wereevaluated in 1291 subjects (937 men, 354women) by a questionnaire. The fat distributionpattern was assessed by measurement of thewaist/hip (W/H) ratio. BP was measured twice witha semiautomatic oscillometric measurementdevice. The W/H ratio and sys/dia BP according toEC frequency are summarized in table 1 :Ethanol n W/H- sys BP dla BPconsumption ratio (mmHQ) (mmHQ)< 1 daYiweek 442 0.87 123 761-2 daYs/week 473 0.90 123 773-4 daYs/week 201 0.93 127 79..daily 175 0.93 128 80A multiple regression model showed that aftersex, age and absolute body weight ethanolconsumption was the major determinant of theW/H ratio and BP. Our data suggest that ethanolconsumption is associated with increasedabdominal fat deposition which leads to a higherblood pressure.ethanol, alcohol, hypertension, fatKeyWords: distribution129DYSLIPIDEMIA, INSULIN RESISTANCE AND BLOOD PRESSURESTATUS IN NON-OBESE, JAPANESE POPULATIONS:COMPARISONS BETWEEN YOUNG AND ELDERLY SUBJECTS.K. Masuo', H. Mikami", T. Ogihara*, and M.L Tuck1*. Dept.Geriatric Medicine, Osaka Univ. Medical School, Osaka, japan,and 1UCLA School of Medicine, Los Angeles, CA.To evaluate the relationships among dyslipidemia, reducedinsulin sensitivity or insulin resistance, and blood pressurein young and elderly, non-obese, japanese males who are livingin Osaka, japan, we undertook this study. In 862 males,consisting of 454 young (22-65 yrs, 45±.5 (SO) yrs) and 408elderly (66-93 yr s, 78±.3 yrs) subjects, blood pressure, fastingblood glucose (BG), fasting plasma insulin (lNS) andnorepinephrine (NE). total cholesterol (T-ch), triglyceride(TG), HDL-eh, VLDL-ch, LDL-ch were measured after more than12 hrs fasting in supine position. None had extreme obesity,diabetes nor family history of diabetes. Young and elderlysubjects were matched in body mass index (22.8±.l.0 vs22.7±.0.8kg/rri-) and BP status (number of NT:BHT:EHT,226:120:108 vs 200:119:89). BG and INS were also measuredevery 30 min for 2 hrs after 7Sg glucose ingestion to calculatearea under the curve (AUC) for BG and INS. Fasting BG, T-ch,VLDL, TG and AUC for INS were significantly greater in elderlysubjects than those in young subjects, but AUC for BG wassimilar to each other. In young subjects, only T-ch and fastingINS correlated significantly with mean BP (R~0.39, P=0.021,R~0.56, P~O.012), on the other hand, in elderly subjects, TGand VLDL-eh correlated significantly with mean BP(R~O.38,P~O.029, R~0.49, P=O.025), but T-ch did not. In all subjects,regardless of BP status and age, TG, VLDL-ch and fasting INScorrelated with mean BP, systolic BPand diastolic BP, and TGand fasting INS correlated with BM!. These results suggest INSresistance and dyslipidemia appears to be responsible for BPlevels in non-obese japanese male.KeyWords: dyslipidemia, insulin resistance,blood pressure, aging, BM!KeyWords: insulin resistance, dyslipidemia, bloodpressure, aging

I27IS THE EFFECT OF ETHANOL ON BLOOD PRESSURE INDUCED BY AN INCREASED WAIST/HIP RATIO?

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