This working paper presents the main challenges that Latin America will face in the coming years, within a global context of greater fragmentation, conflict, and disorder, known as "Cold Peace". Over a medium and long-term time horizon, it is possible to identify 5 megatrends: climate change and energy, new technological developments, population, inequality and emerging middle classes, and urban development. The region should avoid the risk of irrelevance and isolation, especially in the face of the geopolitical and economic transition towards Asia as the new center of gravity. Therefore, Latin America needs to enhance its capacity to influence and to address the most critical issues such as creation of wealth and prosperity, peace and social inclusion, and productivit