Efficient Semiparametric Estimation of Average Treatment Effects Under Covariate Adaptive Randomization

Abstract

Experiments that use covariate adaptive randomization (CAR) are commonplace in applied economics and other fields. In such experiments, the experimenter first stratifies the sample according to observed baseline covariates and then assigns treatment randomly within these strata so as to achieve balance according to pre-specified stratum-specific target assignment proportions. In this paper, we compute the semiparametric efficiency bound for estimating the average treatment effect (ATE) in such experiments with binary treatments allowing for the class of CAR procedures considered in Bugni, Canay, and Shaikh (2018, 2019). This is a broad class of procedures and is motivated by those used in practice. The stratum-specific target proportions play the role of the propensity score conditional on all baseline covariates (and not just the strata) in these experiments. Thus, the efficiency bound is a special case of the bound in Hahn (1998), but conditional on all baseline covariates. Additionally, this efficiency bound is shown to be achievable under the same conditions as those used to derive the bound by using a cross-fitted Nadaraya-Watson kernel estimator to form nonparametric regression adjustments