CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Exposure to Epstein-Barr virus infection is associated with mild systemic lupus erythematosus disease
Authors
Juan-Manuel Anaya
Ori Barzilai
+7 more
Yackov Berkun
Miri Blank
Mona Boaz
Maya Ram
Yaniv Sherer
Yehuda Shoenfeld
Gisele Zandman?Goddard
Publication date
26 May 2020
Publisher
'Wiley'
Doi
Cite
Abstract
Infections may act as environmental triggers for the induction of systemic lupus erythematosus (SLE). In this study, we determine the relationship between disease manifestations of SLE patients and the titers of five Epstein-Barr virus (EBV) Abs. We evaluated the titers of early antigen IgG (EAG), nuclear antigen IgG, viral capsid antigen (VCA) IgG and IgM, and heterophile IgM, using the BioPlex 2200 multiplexed immunoassay method in 260 sera (120 SLE patients and 140 controls). EAG titers were significantly elevated (P less than 0.024) in patients with cutaneous symptoms and increased anti-Ro antibody titers (P less than 0.005). VCA IgG titers were significantly elevated (P less than 0.003) in patients with joint involvement. None of the titers differed by central nervous system or renal involvement or antiphospholipid syndrome. We conclude that exposure to EBV infection may predict a disease phenotype of mild SLE disease with cutaneous and joint manifestations and elevated titers of anti-Ro Abs. © 2009 New York Academy of Sciences
Similar works
Full text
Available Versions
edocUR
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:repository.urosario.edu.co...
Last time updated on 03/06/2020