Acute poisonings by drugs used for cardiovascular diseases treatment are less
frequent than poisonings by other drugs, but often lead to serious disorders in various organ
systems and are characterized by relatively high mortality. When it comes to polydrug
poisoning by drugs with a depressant effect on the cardiovascular system, hospital care of
the patients is necessary. This research aimed to present data on acute poisonings by drugs
used in the cardiovascular diseases treatment in the Republic of Serbia in the period 2010-
2018 based on the published Annual reports of the National Poison Control Center of the
Military Medical Academy (1). Number of patients examined on suspicion of poisoning by
drugs for cardiovascular diseases treatment, in the period 2010-2018, ranged from 4-6% of
all examined due to acute drug poisoning per year, while number of hospitalizations due to
drug poisoning ranged from 7 to 11% of all hospitalized patients. Of the total number of
deaths resulting from drug poisoning, 27% are patients who died due to the poisoning by
drugs used for cardiovascular diseases treatment. The most common causes of poisoning in
the examined patients were beta blockers (45%), followed by Ca 2+ channel blockers (25%)
and ACE inhibitors (21%), and these three groups of drugs are the most common causes in
hospitalized patients as well. Lethal outcomes are most often the result of acute poisoning by
Ca 2+ channel blockers (50%) and beta blockers (40%), mainly in combination with drugs
used in psychiatric illnesses treatment, such as benzodiazepines, antiepileptics and
antipsychotics.Akutna trovanja lekovima za lečenje kardiovaskularnih bolesti su ređa u odnosu na
trovanja drugim lekovima, ali često dovode do ozbiljnih poremećaja u funkcionisanju
različitih sistema organa i karakterišu se relativno visokim mortalitetom. Kada su u pitanju
polimedikamentozna trovanja lekovima koji imaju depresorno dejstvo na kardiovaskularni
sistem, neophodno je bolničko zbrinjavanje pacijenata. Cilj ovog rada je bio prikazati analizu
podataka o akutnim trovanjima lekovima koji se koriste u terapiji kardiovaskularnih
oboljenja u Republici Srbiji u periodu od 2010 do 2018. godine na osnovu publikovanih
Godišnjaka Nacionalanog centra za kontrolu trovanja Vojnomedicinske akademije (1). Broj
pacijenata koji su pregledani pod sumnjom na trovanje lekovima za lečenje
kardiovaskularnih bolesti u periodu 2010-2018. godine kretao se od 4-6% svih pacijenata
pregledanih usled akutnog trovanja lekovima godišnje, dok se broj pacijenata
hospitalizovanih usled trovanja lekovima kretao 7-11% svih hospitalizovanih pacijenata. Od
ukupnog broja letalnih ishoda koji su posledica trovanja lekovima, 27% čine pacijenti
preminuli zbog trovanja lekovima za lečenje kardiovaskularnih bolesti. Najčešći uzročnici
trovanja kod pregledanih pacijenata su beta blokatori (45%), zatim blokatori Ca 2+ kanala
(25%) i ACE inhibitori (21%), a ove tri grupe lekova su najzastupljenije i kod
hospitalizovanih pacijenata. Letalni ishodi su najčešće posledica akutnog trovanja
blokatorima Ca 2+ kanala (50%) i beta blokatorima (40%), uglavnom u kombinaciji sa
lekovima koji se koriste u terapiji psihijatrijskih oboljenja poput benzodiazepina,
antiepileptika i antipsihotika.VIII Kongres farmaceuta Srbije sa međunarodnim učešćem, 12-15.10.2022. Beogra
