Faculty of Engineering, School of Chemical and Biomolecular Engineering
Abstract
The digestive system is vital to the human body. Over many decades, scientists have been
investigating the food breakdown mechanisms inside the stomach through in vivo human and animal
studies and in vitro experiments. Due to recent improvements in computing speed and algorithm
development, computational modelling has become a viable option to investigate in-body processes.
Such in silico models are more easily controlled to investigate individual variables, do not require
invasive physical experiments, and can provide valuable insights into the local physics of gastric flow.
There is a huge potential for numerical approaches in stomach modelling as they can provide a
comprehensive understanding of the complex flow and chemistry in the stomach. However, to make
sure the numerical methods are accurate and reliable, rigorous verification and validation are
essential as part of model development. A significant focus of this thesis was on verifying and
validating the numerical modelling approaches pertinent to stomach modellin
