This thesis reports on the synthesis, development and validation of a novel, non-toxic dual modal bio-imaging probe that targets a conformational molecular switch and relocalisation of cell surface Endo180 into endosomes that occurs during the early stages of aggressive prostate cancer.InP/ZnS quantum dots were synthesised using a successive heating methodology following the introduction of a cooling phase between the addition of ‘shelling’ precursors. Photoluminescent quantum yields following the synthesis of InP/ZnS (2) quantum dots are reported at 85.30% in hexane and 57% in water (following phase transfer).An OI/MR dual-modal imaging probe was successfully synthesised following the surface modification of InP/ZnS (2) – TGA with Ln(III) DOTA chelate derivative (Ln = Gd, Eu and Tb). Up to 190 Gd(III) chelates were added to the surface of InP/ZnS (2) – TGA resulting in a combined r1 value of 1609.94 mM-1s-1 (InP/ZnS (2) – Gd.5a) when InP/ZnS (2) is synthesised with InI3. High values of photoluminescent quantum yield were achieved of up to 19.9% (InP/ZnS (2) – Gd.5.b) with no shift in emission properties observed following surface functionalisation when compared to InP/ZnS (2) – TGA.A targeted dual modal OI/MR imaging probe for the early detection of aggressive prostate cancer has been developed, via a two-step surface modification of InP/ZnS (2) – TGA with Endo180 conformational specific antibodies (A5.158, 39.10) and Gd(III) chelate (Gd.5a).Work presented in chapter 2 has formed part of the publication, Clarke, M. T.; Viscomi, N.; Chamberlain, T. W.; Hondow, N.; Adawi, A. M.; Sturge, J.; Erwin, S. C.; Bouillard, J.-S. G.; Tamang, S.; Stasiuk, G. J. Near Unity Quantum Yield in InP Based Quantum Dots through Thermal Diffusion. Commun. Chem. 2019, 2
