Hepatoprotective Activities Of Methanolic Extract Of Nauclea Latifolia

Abstract

The hepatoprotective activity of the root bark extract of Nauclea latifolia was tested in vivo. The root bark was defatted with diethyl ether and then extracted with methanol and the methanolic extract was recovered on a 9.3 % w/w yield. The LD50 of the methanolic extract in rats was 300 mg/kg (i.p). It showed no significant effect on pentobarbital-induced sleep in rats after i.p. injection. The extract significantly reduced pentobarbital-induced sleep in paracetmol and carbon tetrachloride (CCl4) intoxicated rats. The elevataion of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and alkaline phosphatase (AP) induced by paracetamol and CCl4 intoxication in rats was also significantly (

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