Globally, the prevalence of infertility ranges from 8 - 12%, but in Sub-Saharan Africa, it is 20 - 32%. The advent of assisted reproductive technology brought hope and has become a huge solution to the social and public health challenge of infertility. However, infertile women with poor ovarian reserve remain a frustrating dilemma to fertility experts worldwide. We report the case of a 32-year-old poor ovarian responder who was successfully treated with in-vitro fertilisation followed by two-step cleavage-stage and then blastocyst-stage embryo transfers in Ghana that resulted in twin live birth