Despite being extremely old concepts, plasmonics and surface plasmon
resonance-based biosensors have been increasingly popular in the recent two
decades due to the growing interest in nanooptics and are now of relevant
significance in regards to applications associated with human health.
Plasmonics integration into point-of-care devices for health surveillance has
enabled significant levels of sensitivity and limit of detection to be achieved
and has encouraged the expansion of the fields of study and market niches
devoted to the creation of quick and incredibly sensitive label-free detection.
The trend reflects in wearable plasmonic sensor development as well as
point-of-care applications for widespread applications, demonstrating the
potential impact of the new generation of plasmonic biosensors on human
well-being through the concepts of personalized medicine and global health. In
this context, the aim here is to discuss the potential, limitations, and
opportunities for improvement that have arisen as a result of the integration
of plasmonics into microsystems and lab-on-chip over the past five years.
Recent applications of plasmonic biosensors in microsystems and sensor
performance are analyzed. The final analysis focuses on the integration of
microfluidics and lab-on-a-chip with quantum plasmonics technology prospecting
it as a promising solution for chemical and biological sensing. Here it is
underlined how the research in the field of quantum plasmonic sensing for
biological applications has flourished over the past decade with the aim to
overcome the limits given by quantum fluctuations and noise. The significant
advances in nanophotonics, plasmonics and microsystems used to create
increasingly effective biosensors would continue to benefit this field if
harnessed properly