Chitosan is a natural polymer obtained by deacetylation of chitin. Due to its biocompatibility and biodegradability, chitosan-based materials have a wide range of biomedical applications in wound dressings, drug delivery systems, and tissue engineering. Also, studies in the fields of organic and medicinal chemistry show that compounds based on the pyridone core exhibit biological properties including antimicrobial, anticancer, and antioxidant activity, and moreover have the potential as new therapeutics for various diseases from cardiovascular to antitumor therapy. In this study, new biomaterials were synthesized using low and medium molecular weight chitosan polymers and pyridone-based hydrazone. In order to improve stability of the obtained scaffolds, scaffolds’ neutralization was carried out using ethanol and sodium hydroxide solutions. The interactions established between chitosan polymer chains and pyridone compound were analyzed by FT-IR spectroscopy. Swelling and degradation tests of the materials were studied in water and PBS, and the influence of different polymer molecular weights on the scaffolds’ properties was evaluated. The results indicated that synthetized scaffolds have a high potential for biomedical use
