Slooter, M.D.

English

This thesis addresses a number of applications of dynamic fluorescence-guided surgery. Dynamics of fluorescent agents were investigated, including an activatable fluorescent agent to detect close resection margins during oral cancer surgery, elimination by the kidneys, and tissue perfusion, also known as fluorescence angiography (FA). For FA, the aim was to evaluate time to fluorescence as a quantitative parameter to derive a threshold for patient outcomes. By adding time to FA, a continuous value provided additional information to the static fluorescence image, and allowed for quantification of perfusion in patients undergoing gastrointestinal surgery

International Migration, Integration and Social Cohesion online publications

UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl)UvA-DARE (Digital Academic Repository)Dynamic fluorescence-guided surgeryThe road towards defining greenSlooter, M.D.Publication date2021Link to publicationCitation for published version (APA):Slooter, M. D. (2021). Dynamic fluorescence-guided surgery: The road towards defininggreen. [Thesis, fully internal, Universiteit van Amsterdam].General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s)and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an opencontent license (like Creative Commons).Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, pleaselet the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the materialinaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letterto: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. Youwill be contacted as soon as possible.Download date:10 Mar 2023Dynamic fluorescence-guided surgeryThe road towards defining greenDynamic fluorescence-guided surgery                                                                     Maxime Slooter Maxime SlooterUitnodigingVoor het (online) bijwonen van de openbare verdediging van het proefschriftDynamic fluorescence-guided surgeryThe road towards defining greendoor Maxime SlooterOp vrijdag 9 april 2021 om 11.00 uurOude Lutherse KerkUniversiteit van AmsterdamSingel 411, 1012 WN te AmsterdamParanimfenBarbara Slooter06 53902714Fenna van de Leemkolk06 30410305promotiemaximeslooter@gmail.comMaxime SlooterVechtstraat 36-HS1078 RM Amsterdam  mdslooter@hotmail.com 06 48926318Dynamic fluorescence-guided surgeryThe road towards defining greenMaxime SlooterCopyright © M.D. Slooter, 2021ISBN: 978-6332-739-8Lay-out: Loes KemaPrinted by: GVO Drukkers & Vormgevers, EdeParanimfen: Barbara Slooter, Fenna van de LeemkolkAll rights reserved. Part of the research described in this thesis was financially supported by Stryker European Operations B.V. Financial support for the printing of this thesis is gratefully acknowledged to: Wetenschappelijk fonds Chirurgie (Amsterdam UMC, locatie AMC, Univerisiteit van Amsterdam), B. Braun.Dynamic fluorescence-guided surgeryThe road towards defining greenACADEMISCH PROEFSCHRIFTter verkrijging van de graad van doctoraan de Universiteit van Amsterdamop gezag van de Rector Magnificusprof. dr. ir. K.I.J. Maexten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigenop vrijdag 9 april 2021, te 11.00 uurdoor Maxime Danielle SlooterGeboren te LeidenPromotiecommissiePromotores:  prof. dr. M.I. van Berge Henegouwen AMC-UvA  prof. dr. P.J. Tanis     AMC-UvACo-promotores:  dr. R. Hompes     AMC-UvA  dr. D.M. de Bruin     AMC-UvAOverige leden: Prof. dr. M.C.G. Aalders    Universiteit van Amsterdam  Prof. dr. M.A. Boermeester    AMC-UvA  Prof dr. R. Cahill     University College Dublin  Prof. dr. J.P. Ruurda      Universiteit Utrecht  Dr. R.J. Swijnenburg     AMC-UvA  Dr. A.L. Vahrmeijer    LUMCFaculteit der GeneeskundeVoor mijn opa’s en oma’sContentsChapter 1 General Introduction and Thesis Outline 11Chapter 2 Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase19Chapter 3 Currently available and experimental dyes for intraoperative near-infrared fluorescence imagingof the ureters: a systematic review35Chapter 4 Near infrared fluorescence angiography of a pedicled omentoplasty for pelvic reconstruction: a pilot study53Chapter 5 Optimizing omentoplasty for management of chronic pelvic sepsis by intraoperative fluorescence angiography: a comparative cohort study65Chapter 6 Fluorescent imaging using indocyanine green during esophagectomy to prevent surgical morbidity: a systematic review and meta-analysis83Chapter 7 IMARI: multi-Interventional program for prevention and early Management of Anastomotic leakage after low anterior resection in Rectal cancer patIents: rationale and study protocol101Chapter 8 Defining indocyanine green fluorescence to assess anastomotic perfusion during gastrointestinal surgery:a systematic review119Chapter 9 Fluorescence perfusion assessment of vascular ligation during ileal pouch-anal anastomosis143Chapter 10 Quantitative fluorescence-guided perfusion assessment of the gastric conduit to predict anastomotic complications after esophagectomy161Chapter 11 Comparison of optical imaging techniques to quantitatively assess perfusion of the gastric conduit during oesophagectomy179Chapter 12 General discussion and future perspectives 197Appendices Summary 213Nederlandse samenvatting (Dutch summary) 219List of contributing authors 225List of publications 231PhD portfolio 235Curriculum Vitae 239Dankwoord 241

Dynamic fluorescence-guided surgery:The road towards defining green

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Dynamic fluorescence-guided surgery:The road towards defining green

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International Migration, Integration and Social Cohesion online publications