Legemaat, A.M.

English

This thesis focuses on cognitive remediation and recurrence prevention in Major Depressive Disorder (MDD). It includes a meta-analysis on cognitive remediation in depression, which indicates that cognitive remediation improves cognitive functioning on the short term. Effects on depressive symptomatology and daily functioning, however, may have been overestimated.Furthermore, we performed a 20-year follow-up of a randomized controlled trial on Preventive Cognitive Therapy in adults remitted from recurrent MDD. Although several limitations of this study preclude firm conclusions, the findings suggest long-term protective effects of Preventive Cognitive Therapy up to 20 years. This thesis also includes the protocol for a randomized controlled trial on Preventive Cognitive Therapy augmented by online neurocognitive remediation therapy. We hypothesize that this combination of treatments, targeting multiple underlying mechanisms in depression simultaneously, may reduce chronicity in partial remitted MDD. We conducted the first systematic review ever on neuropsychological performance validity in MDD. A surprisingly small number of studies reported on performance validity in MDD and about 94% of patients had valid performance. Our findings indicate that cognitive impairment might be limited in patients with valid performance and underscore the importance of taking neuropsychological performance validity into account. Considering the new insights gained from the studies in this thesis, we conclude that an integrated approach of treatments may be required in order to optimize outcomes for patients with MDD

International Migration, Integration and Social Cohesion online publications

UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl)UvA-DARE (Digital Academic Repository)Breaking the cycle of depressionTowards targeting multiple underlying mechanismsLegemaat, A.M.Publication date2022Link to publicationCitation for published version (APA):Legemaat, A. M. (2022). Breaking the cycle of depression: Towards targeting multipleunderlying mechanisms. [Thesis, fully internal, Universiteit van Amsterdam].General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s)and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an opencontent license (like Creative Commons).Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, pleaselet the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the materialinaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letterto: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. Youwill be contacted as soon as possible.Download date:10 Mar 2023Breaking the cycle of depression        amanda manuela legemaatBreaking the cycle of depression amanda manuela legemaatTowards targeting multiple underlying mechanismsomslag_amanda_legemaat.indd   1 13-9-2022   11:32:16omslag_amanda_legemaat.indd   2 13-9-2022   11:32:16Amanda Manuela LegemaatBreaking the cycle of depressionTowards targeting multiple  underlying mechanismsCover image J. Sayuri | Human (Homo sapiens) axial viewLayout Renate Siebes | Proefschrift.nuPrinted by Proefschriftmaken, De BiltISBN 978-94-90791-98-8© 2022 Amanda Legemaat All rights reserved. No part of this dissertation may be reprinted, reproduced, or utilized in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording or any information storage or retrieval system, without prior written permission of the author.Breaking the cycle of depressionTowards targeting multiple  underlying mechanismsACADEMISCH PROEFSCHRIFTter verkrijging van de graad van doctoraan de Universiteit van Amsterdamop gezag van de Rector Magnificus prof. dr. ir. P.P.C.C. Verbeekten overstaan van een door het College voor Promoties ingestelde commissie,in het openbaar te verdedigen in de Aula der Universiteitop woensdag 2 november 2022, te 11.00 uurdoor Amanda Manuela Legemaatgeboren te MaastrichtPromotiecommissiePromotores:    prof. dr. C.L.H. Bockting   AMC-UvAprof. dr. D.A.J.P. Denys  AMC-UvACopromotores:    dr. H. Burger    Rijksuniversiteit Groningendr. G.J. Geurtsen    AMC-UvAOverige leden:  prof. dr. B.A. Schmand   AMC-UvAprof. dr. R.W.H.M. Ponds   Vrije Universiteit Amsterdamprof. dr. S.B. Schagen   Universiteit van Amsterdamprof. dr. A. Aleman   Rijksuniversiteit Groningenprof. dr. M.J.E. van Zandvoort   Universiteit Utrechtprof. dr. C.A.M. van Bennekom   AMC-UvAFaculteit der Geneeskunde1 7 General introduction23 Effectiveness of cognitive remediation in depression: a meta-analysis 23 61 Enduring effects of Preventive Cognitive Therapy in adults remitted from recurrent depression: the DELTA study 20-year follow-up79 Augmenting neurocognitive remediation therapy to Preventive Cognitive Therapy for partial remitted depressed patients: protocol of a pragmatic multi-centre randomised controlled trial 45103 Is suboptimal effort an issue? Neuropsychological performance validity in major depressive disorder: a systematic review and meta-analysis131 General discussion 6149 English summary153 Dutch summary / Nederlandse samenvatting 159 About the author160 Curriculum vitae161 PhD portfolio165 Acknowledgements / DankwoordTable of conTenTs

Breaking the cycle of depression:Towards targeting multiple underlying mechanisms

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Breaking the cycle of depression:Towards targeting multiple underlying mechanisms

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International Migration, Integration and Social Cohesion online publications