Scheres, L.J.J.

English

In this thesis the aim was threefold: 1) to examine sex-specific differences to advance the understanding of underlying mechanisms in thrombosis 2) to improve models for risk assessment in thrombosis by identifying women-specific predictors and critically appraise existing risk assessment models developed for women 3) to further improve strategies for women-specific management of thrombosis and thrombophilia

International Migration, Integration and Social Cohesion online publications

UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl)UvA-DARE (Digital Academic Repository)Sex, hormones & clotsSex-specific mechanisms and women-specific models for risk assessment & management inthrombosisScheres, L.J.J.Publication date2019Document VersionOther versionLicenseOtherLink to publicationCitation for published version (APA):Scheres, L. J. J. (2019). Sex, hormones & clots: Sex-specific mechanisms and women-specific models for risk assessment & management in thrombosis. [Thesis, fully internal,Universiteit van Amsterdam].General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s)and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an opencontent license (like Creative Commons).Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, pleaselet the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the materialinaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letterto: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. Youwill be contacted as soon as possible.Download date:09 Mar 2023sSex, Hormones & Clotssex-specific mechanisms and women-specific models for risk assessment & managementin thrombosisLuuk J.J. ScheresSex, Hormones & Clots:sex-specific mechanisms and women-specific models for risk assessment & management in thrombosisLuuk J.J. ScheresColofonCopyright © L.J.J. Scheres, 2019No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without prior written permission of the author. ISBN 978-94-6375-376-0Author: Luuk J.J. ScheresCover design and layout: Sandra BoksCover image: Georges Seurat, Le Chahut, 1889-1890 © Collection Kröller-MüllerMuseum, Otterlo, the Netherlands. Printed with permission. Printing: Ridderprint BV, www.ridderprint.nl The research described in this thesis was supported by a grant of the Dutch Heart Foundation (DHF 2013T083)Finanical support for printing this thesis was kindly provided by Stichting tot Steun Promovendi Vasculaire Geneeskunde, Bayer, Daiichi Sankyo, Federatie Nederlandse Trombosediensten, LEO Pharma, and Pfizer. Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.Sex, Hormones & Clots:sex-specific mechanisms and women-specific models for risk assessment & management in thrombosisACADEMISCH PROEFSCHRIFTter verkrijging van de graad van doctoraan de Universiteit van Amsterdamop gezag van de Rector Magnificusprof.dr.ir. K.I.J. Maexten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op vrijdag 21 juni 2019, te 14.00 uur doorLuuk Joseph Jacob Scheres geboren te GeleenPromotiecommissiePromotores:  prof. dr. S. Middeldorp  AMC-UvA  prof. dr. S.C. Cannegieter Universiteit LeidenCopromotor:  dr. W.M. Lijfering Universiteit LeidenOverige leden: prof. dr. M. Goddijn AMC-UvA  prof. dr. G.K. Hovingh AMC-UvA  prof. dr. P.M.M. Bossuyt AMC-UvA  prof. dr. M.J.H. Wermer Universiteit Leiden  prof. dr. M.V. Huisman Universiteit Leiden  prof. dr. F.M. Helmerhorst Universiteit LeidenFaculteit der GeneeskundeTABLE OF CONTENTS Chapter 1 General introduction and overview 9Chapter 2 Current and future burden of venous thrombosis:  19 not simply predictable PART I: SEX-SPECIFIC MECHANISMS Chapter 3 Epidemiology of venous thromboembolism: 49 the influence of sex and siteChapter 4 Sex-specific differences in the presenting location  75 of a first venous thromboembolismChapter 5 Sex-specific differences in the distal versus  93 proximal presenting location of acute deep vein  thrombosisChapter 6 Effect of gender affirming hormone use on  111 coagulation profiles in transmen and transwomenChapter 7 Endogenous sex hormones and risk of venous  131 thromboembolism in young womenPART II:WOMEN-SPECIFIC MODELS FOR RISK ASSESSMENTChapter 8 Hypertensive complications of pregnancy and  153 risk of venous thromboembolismChapter 9 Cardiovascular risk prediction models for women  173 in the general population: a systematic reviewPART III: WOMEN-SPECIFIC MANAGEMENT Chapter 10 Abnormal vaginal bleeding in women with  199 venous thromboembolism treated with apixaban  or warfarinChapter 11 Abnormal vaginal bleeding in women of  217 reproductive age treated with edoxaban or  warfarin for venous thromboembolism: a post  hoc analysis of the Hokusai-VTE studyChapter 12 Aspirin or heparin or both for improving  239 pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent  pregnancy lossChapter 13 Summary and perspectives 293APPENDICESNederlandse samenvatting 306List of publications 314Authors and affiliations 316Portfolio  321About the author 327Dankwoord  328

Sex, hormones &amp; clots:Sex-specific mechanisms and women-specific models for risk assessment &amp; management in thrombosis

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Sex, hormones & clots:Sex-specific mechanisms and women-specific models for risk assessment & management in thrombosis

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International Migration, Integration and Social Cohesion online publications

Sex, hormones &amp; clots:Sex-specific mechanisms and women-specific models for risk assessment &amp; management in thrombosis

Abstract

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Full text

Available Versions

International Migration, Integration and Social Cohesion online publications

Sex, hormones & clots:Sex-specific mechanisms and women-specific models for risk assessment & management in thrombosis