Amey, Marlyse

Annen, O.

Baumann, Pierre

Chardon, F.

Hatzinger, Martin

Hemmeter, Ulrich

Holsboer-Trachsler, Edith

Müller, M.J.

Seifritz, Erich

Pharmacokinetic measurements, neuroendocrine responses, and side effects profiles of intravenous infusions of 20 mg citalopram over 30 minutes during the early afternoon have been studied. Eight healthy male volunteers were enrolled in a placebo- (saline) controlled, single-blind, cross-over protocol. Plasma concentrations of the parent compound showed a double exponential decay. Demethyl and didemethyl metabolites were not detectable, but low concentrations of the propionic acid derivative of citalopram were found. Determination of the citalopram enantiomers yielded a balanced S(+)/R(-) ratio of 0.9 to 1.2. The endocrine response to the drug was characterized by significant increases in plasma prolactin and cortisol. Except for one subject, who developed pronounced side effects, human growth hormone showed a surge following saline that was inhibited following citalopram. Rectal temperature and heart rate were not affected and tolerability was favorable. Because of citalopram's extremely high selectivity for the presynaptic 5-hydroxytryptamine nerve terminals, the present data suggest that it might be a promising tool for the investigation of serotonergic function in the human brain in vivo

Seifritz, E.

Baumann, P.

Amey, M.

Hemmeter, U.

Hatzinger, M.

Holsboer-Trachsler, E.

Serveur académique lausannois

Neuroendocrine effects of a 20-mg citalopram infusion in healthy males. A placebo-controlled evaluation of citalopram as 5-HT function probe.

Neuroendocrine effects of a 20-mg citalopram infusion in healthy males - A placebo-controlled evaluation of citalopram as 5-HT function probe

Neuroendocrine effects of a 20-mg citalopram infusion in healthy males - A placebo-controlled evaluation of citalopram as 5-HT function probe

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Serveur académique lausannois