Sugden, Kent D.

English

University of Montana

University of Montana ScholarWorks at University of Montana University of Montana Course Syllabi, 2011-2015 Fall 9-1-2015 BCH 380.00: Biochemistry Kent D. Sugden University of Montana, Missoula, kent.sugden@umontana.edu Follow this and additional works at: https://scholarworks.umt.edu/syllabi2011-2015 Let us know how access to this document benefits you. Recommended Citation Sugden, Kent D., "BCH 380.00: Biochemistry" (2015). University of Montana Course Syllabi, 2011-2015. 30. https://scholarworks.umt.edu/syllabi2011-2015/30 This Syllabus is brought to you for free and open access by ScholarWorks at University of Montana. It has been accepted for inclusion in University of Montana Course Syllabi, 2011-2015 by an authorized administrator of ScholarWorks at University of Montana. For more information, please contact scholarworks@mso.umt.edu. 1  BIOC 380--Fundamentals of Biochemistry--Autumn 2015 Instructor Information. Instructor:     Prof. Kent Sugden, Kent.Sugden@umontana.edu Office hours:   M,W,F 11-12 (Chem 306) or by appointment  Text:     “Biochemistry: A Short Course” by Tymoczko, Berg and Stryer 2nd ed Course Aims  • understanding the chemical and thermodynamic properties of biomolecules   • knowledge of the 4 classes of biomolecules, including structure, synthesis and function.  • understanding the catalytic and regulatory strategies of enzymes   • understanding the production, use and regulation of energy in the cell   • understanding how biochemical reactions are integrated into cellular metabolism  Prerequisites:   Biochemistry is a sub-discipline of chemistry, so students should have a good working knowledge of general chemistry and organic chemistry. It is a good idea to review basic chemical concepts as well as organic reactions, nomenclature and functional groups.  Course Requirements  Students are expected to study the text and should read the text prior to the corresponding lectures. Questions for each chapter are given in the text and it is suggested that you review these problems.  However, homework will not be collected or graded.  Lecture and discussion format  The Monday, Wednesday, and Friday lectures will cover material from the text.  Additionally, each student is required to attend one smaller group discussion section, which is scheduled on 10:10 – 11:00 or 11:10-12:00. Material covered in the discussion periods will typically be of clinical/medical, or physiological relevance and students may be responsible for this material on subsequent quizzes and exams. The discussion sessions will also serve as a time to ask questions and to clarify course material and to administer weekly quizzes on weeks without exams. On three Tuesdays during the semester the entire class will meet at 10:10 am in lieu of discussion periods for midterm exams.  Grading  There are weekly quizzes given in discussion sections. In addition there will be four exams, consisting of three one hour exams (given on Tuesdays during discussion section time) and one comprehensive final exam. The lowest score of the three midterm exams will be dropped, but the final exam score cannot be dropped.  Final grades will be assigned as: 90-100% = A, 80-89% = B; 70-79% = C; 60-69% = D; below 60% = F. Plusses and minuses may be used at the discretion of the instructor. Changes to this grading scheme is at the discretion of the instructor.  2  Missed Quizzes and Exams  The two lowest (or missed) quiz grades will be dropped, makeup quizzes will not be given. Students will have the the lowest of the three midterm exams dropped so there will be no exceptions for a missed exam. THERE IS NO EXTRA CREDIT. General Policies  If you are taking the course for a non-traditional grade (credit/no credit), note that university policy is that a “CR” grade is given in lieu of A through D- grade; an “NCR” grade is given in lieu of an F grade.  The use of any external device including electronic devices such as calculators and translators for quizzes and exams requires the advanced approval of the instructor.  All students must practice academic honesty. Academic misconduct is subject to an academic penalty by the course instructor and/or a disciplinary sanction by the University. All students need to be familiar with the Student Conduct Code. The Code is available for review online at http://life.umt.edu/sa/vpsa/index.cfm/page/2585 Special accommodations   If you are registered with Disability Student Services and require special accommodations, please contact Prof. Sugden to make arrangements prior to the day of testing. Tests or quizzes taken at DSS must be the same day and must overlap the same time period as that of the rest of the class.  Lecture Schedule (Chapter #’s based on 2nd edition of book)  WEEK 1 M 8/31 Course introduction, Chapter 1 W 9/2 Chapter 2- Water, pH, buffers F 9/4 Chapter 2- Water, pH, buffers Discussion Sections: Tu 9/1 No discussion sections in first week. No Quiz   WEEK 2 M 9/7 No class- Labor Day W 9/9 Chapter 3- amino acids F 9/11 Chapter 4- protein structure Note that we skip Chapter 5 on Techniques in Protein Biochemistry Discussion Sections:  Tu 9/8: Organic Chemistry Review Quiz 1: Chapters 1 and 2  WEEK 3 M 9/14 Chapter 6- Enzyme properties W 9/16 Chapter 7- Enzyme kinetics F 9/18 Chapter 8 – Enzyme Mechanisms and Inhibitors Discussion Sections:  Tu 9/15:The bicarbonate buffer system Quiz 2: Chapters 3 and 4  3  WEEK 4 M 9/21 Chapter 9- Hemoglobin W 9/23 Chapter 10 – Carbohydrates/polysaccharides F 9/25 Test Review Discussion Sections:  Tu 9/22: Hair protein structure and trichothiodystrophy  Quiz 3: Chapters 6 and 7  WEEK 5 M 9/28 Chapter 10 – Carbohydrates/polysaccharides W 9/30 Chapter 11 – Lipids F 10/2 Chapter 12 – Membranes NO DISCUSSION SECTIONS MEET THIS WEEK Tuesday 9/29 Exam 1: Chapters 1-9; in CHCB 452 at 10:10 am  WEEK 6 M 10/5 Chapter 12 – Membrane Function W 10/7 Chapter 13 – Signal Transduction F  10/9 Chapter 15 – Thermodynamics of Metabolism, ATP, and Vitamins Note that we skip Chapter 14 on digestion! Discussion Sections:  Tu 10/6: Proteases Inhibitors as Drugs  Quiz 4: Chapters 10 and 11  WEEK 7 M  10/12 Chapter 16 – Metabolism Overview and Glycolysis W 10/14 Chapter 16 – Glycolysis F  10/16 Chapter 17 – Gluconeogenesis Discussion Sections:  Tu 10/13: Salmonella Lipid A Structure  Quiz 5: Chapters 12 and 13  WEEK 8 M 10/19 Chapters 18 -- Citric Acid Cycle W 10/21 Chapters 19 – Citric Acid Cycle F  10/23 Test Review Discussion Sections:  Tu 10/20: Imatinib: an inhibitor of Tyrosine Kinase  Quiz 6: Chapters 15 and 16  WEEK 9 M 10/26 Chapter 20 – Electron Transport Chain W 10/28 Chapter 21 – Oxidative Phosphorylation and The Proton-Motive Force F 10/30 Chapter 21 – Oxidative Phosphorylation and The Proton-Motive Force NO DISCUSSION SECTIONS MEET THIS WEEK Tuesday 10/27 Exam 2: Chapters 10 – 19; in CHCB 452 at 10:10 am     4  WEEK 10 M 11/2 Chapters 24 -- Glycogen Metabolism W 11/4 Chapter 25-- Glycogen Synthesis F  11/6 Chapter 26 – Pentose Phosphate Pathway Discussion Sections:  Tu 11/3: Fermentation – merry microbes Quiz 7: Chapters 18 and 19   WEEK 11 M 11/9 Chapter 27 – Fatty Acid Oxidation W 11/11 No Class- Veterans Day F 11/13 Chapter 28– Fatty Acid Synthesis Discussion Sections:  Tu 11/10: Metal Toxicity and Citrate Quiz 8: Chapters 20 and 21   WEEK 12 M 11/16 Chapter 33 – Nucleotides and Nucleic Acid W 11/18 Chapter 34 – DNA Replication F 11/20 Test Review Discussion Sections: Tu 11/17: Diabetes Quiz9: Chapters 27 and 28  WEEK 13 M 11/23 Chapter 35 – DNA Repair and Recombination W 11/25 No Class- Thanksgiving  F 11/27 No Class- Thanksgiving Discussion Sections:  Tu 11/24 :Breast Cancer and DNA Repair Enzymes     Quiz10: Chapters 34 - 35  WEEK 14 M 11/30 Chapter 36 – Transcription in Prokaryotes W 12/2 Chapter 37 – Transcription in Eukaryotes F 12/4 Chapter 38 – RNA Processing NO DISCUSSION SECTIONS MEET THIS WEEK Tuesday 12/1 Exam 3: Chapters 20 – 34; In CHCB 452 at 10:10 am  WEEK 15 M 12/7  Chapters 39 Translation W 12/9 Chapter 40 Translation F 12/11 Review     FINAL EXAM: 75% Comprehensive 25% Chapters 34 – 40 8:00-10:00 am Wednesday 12/16 in FOR 305 

BCH 380.00:  Biochemistry

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BCH 380.00: Biochemistry

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