Nowadays, nanosatellite missions require a development process for the on-board computer (OBC). This process can be optimized using a unique hardware design for different applications. This paper presents the design, implementation and test of a reconfigurable OBC for nanosatellite applications. Reconfigurability is based on ZYNQ architecture that allows an iterative hardware/software co-design approach. The implementation showed an acceptable compatibility with different applications which lead to a successful integration with a custom payload subsystem. These integrated subsystems along with projects from several universities will perform a test flight on August 2022 in the mission FY22 Fort Sumner Campaign sponsored by NASA. In addition, this work can be seen as an open platform to swiftly develop further subsystem implementations.ITESO, A. C