Optimization of nano- and submicro-scaled mesoporous silica particles with tunable surface properties for advanced drug delivery

Abstract

The Si-based submicro- and nanoparticles were prepared using a template sol-gel approach in the presence of cationic surfactants with different length of alkyl chains and alkaline catalysts that allowed a modulation of pore size and surface area of particles in the synthesis mixture to obtain materials with a wide range of size (25-1000 nm) and variable textural characteristics. Mesoporous materials were prepared with the aim to optimize and adapt different synthetic routs for further use of SP as reservoirs for carrying and advanced delivery of therapeutics. © 2018 TANGER Ltd. All Rights Reserved.Ministry of Education, Youth and Sports of the Czech Republic [LO1504]; Science Foundation of the Czech Republic [17-05318S]; Internal Grant of the Tomas Bata University in Zlin [IGA/CPS/2017/005