Immunotoxicology: Modulation of the Immune System by Xenobiotics

Abstract

Starting wih a definition of immunity, this review describes general mechanisms by which immune system is modulated and details several immunotoxicological screening methods to assess the immumologic and host resistance alterations following chemical exposure. Among a variety of immuno toxic compounds known, only four representative compounds namely o-chloro benzylidine malononitrile (CS), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), chloroquine, 1,3 bis (2-chloroethyl) 1-nitrosourea (BCNU) have been chosen for an elaborate discussion

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